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Early diagnosis of infectious diseases is crucial in the fight against global health threats. And in poor and remote areas of the globe where conventional medical tools like microscopes and cytometers are unavailable, RDTs(rapid diagnostic tests) are helping to make disease screening quicker and simpler.

RDTs are generally small strips on which blood or fluid samples are placed. Specific changes in the color of the strip, which usually occur within minutes, suggest the presence of infection. Different tests can be used to detect various diseases, such as such as HIV, malaria, tuberculosis and syphilis.

However, RDTs can also present problems. They are currently read manually, by eye, which is prone to error, especially if various different types of tests are being used by the health care worker. 

To address such challenges, UCLA researchers have developed compact and cost-effective RDT(rapid diagnostic tests)-reading device that works in tandem with standard cell phones.

 "What we have created is a digital 'universal' reader for all RDTs, without any manual decision-making," said Aydogan Ozcan, lead author and a UCLA professor of electrical engineering and bioengineering. 

The RDT-reader attachment clips onto a cell phone. At 65 grams, the attachment consists of an inexpensive lens, three LED arrays, and two AAA batteries. The platform has the ability to read nearly every type of RDT. When a user inserts the RDT strip into the attachment, it is converted into a digital image with the help of cell phone's existing camera unit and a special smart-phone application.  

The platform then rapidly reads the digitized RTD image to determine, first, whether the test is valid and, second, whether the results are positive or negative, thus eliminating the potential errors that can occur with a human reader, especially one administering multiple tests of various test types. And because the color changes in RDTs don't last more than a few hours in the field, the ability to store the digitized image indefinitely provides an added benefit.

After this step, the RDT-reader platform wirelessly transmits the results of the tests to a global server, which processes them, stores them and, using Google Maps, creates maps charting the spread of various diseases and conditions — both geographically and over time — throughout the world.

Together, the universal RDT reader and the mapping feature, which have been implemented on both iPhones and Android-based smart-phones, could significantly increase our ability to track emerging epidemics worldwide and aid in epidemic preparedness, the researchers say.

"This platform would be quite useful for global health professionals, as well as for policymakers, to understand cause–effect relationships at a much larger scale for combating infectious diseases," Ozcan said.

Ozcan's  team have been developing a variety of cell-phone attachments that utilize the digital components already embedded in standard cell phones to aid in the fight against global disease. With more than 5 billion cell-phone subscribers around the world today, cell phones can play a key role in telemedicine applications, and existing wireless telecommunications infrastructure presents new opportunities for innovative cloud-based health-monitoring and management platforms. 

The study is published in the journal Lab on a Chip.