Physical Wellness

7 Health Benefits of Ashwagandha: What Research Says

By Corazon Victorino | Update Date: May 20, 2024 07:52 AM EDT

Ashwagandha, or "Indian ginseng," has been utilized for millennia to combat stress, enhance energy levels, and bolster cognitive prowess, drawing from the rich tapestry of Indian natural healing practices.

Derived from the Sanskrit term meaning "smell of the horse," ashwagandha is revered not only for its distinctive aroma but also for its purported ability to fortify strength and resilience.

Scientifically labeled as Withania somnifera, this botanical gem, also dubbed "winter cherry," boasts a vibrant yellow-flowered shrub native to the lush landscapes of India and Southeast Asia.

Harnessing extracts from its roots or leaves, individuals seek solace from a spectrum of ailments, ranging from anxiety to fertility challenges.

Here are 7 health advantages associated with ashwagandha:

1. Stress and Anxiety Reduction

Ashwagandha stands out for its renowned capacity to alleviate stress, classified as an adaptogen, aiding the body in stress management by modulating key stress mediators such as heat shock proteins (Hsp70), cortisol, and stress-activated c-Jun N-terminal protein kinase (JNK-1). Moreover, it dampens the activity of the hypothalamic-pituitary-adrenal (HPA) axis, a pivotal system regulating the stress response.

Healthline reported, a study involving 60 individuals revealed noteworthy reductions in anxiety levels among those consuming 240 mg of ashwagandha extract daily for 60 days, compared to counterparts receiving a placebo. While preliminary research suggests ashwagandha's potential in mitigating stress and anxiety, a 2021 review of studies cautioned against conclusive recommendations regarding the optimal dosage and formulation of ashwagandha for treating stress-related neuropsychiatric disorders such as anxiety.

2. Mental Health Support

In a particular investigation, scientists examined the impact of ashwagandha on 66 individuals diagnosed with schizophrenia, presenting symptoms of depression and anxiety. Following a regimen of 1,000 mg of ashwagandha extract daily for 12 weeks, participants showcased more pronounced reductions in both depression and anxiety levels compared to those who received a placebo.

Limited findings from a 2013 study also hint at ashwagandha's potential in ameliorating cognitive impairment among individuals grappling with bipolar disorder.

A comprehensive review conducted in 2021 concluded that ashwagandha holds promise in the management of depression, anxiety, insomnia, and various other mental health and neurological concerns.

Nonetheless, further investigation is imperative to comprehensively explore the efficacy of ashwagandha across these diverse applications.

3. Fertility Enhancement

In a specific investigation, 43 males between the ages of 40 and 70, grappling with overweight issues and mild fatigue, were administered tablets containing ashwagandha extract or a placebo on a daily basis for 8 weeks. Results indicated an 18% greater increase in DHEA-S, a sex hormone crucial for testosterone production, among participants who consumed the herb compared to those who received the placebo. Additionally, individuals who took ashwagandha experienced a notable 14.7% rise in testosterone levels in contrast to their counterparts in the placebo group.

Moreover, a comprehensive review of four studies unveiled that ashwagandha treatment substantially augmented sperm concentration, semen volume, and sperm motility in males diagnosed with low sperm count. Encouragingly, it also enhanced sperm concentration and motility in males exhibiting normal sperm count.

While these findings are promising, further research endeavors are warranted to corroborate and expand upon these preliminary outcomes.

4. Blood Sugar Regulation

A review encompassing 24 studies, among which 5 were clinical trials involving diabetic individuals, unveiled compelling outcomes. Ashwagandha treatment was associated with significant reductions in blood sugar levels, hemoglobin A1c (HbA1c), insulin, blood lipids, and oxidative stress markers.

This beneficial effect might be attributed to specific compounds found within ashwagandha, such as withaferin A (WA), known for its potent antidiabetic properties. These compounds may aid in the facilitation of glucose uptake by cells from the bloodstream.

Nevertheless, the current body of research remains limited, necessitating further well-designed studies to elucidate the full scope of ashwagandha's efficacy in managing diabetes and related conditions.

5. Cognitive Enhancement

A review of five clinical studies revealed preliminary evidence suggesting that ashwagandha could enhance cognitive function, particularly in specific demographics like older adults with mild cognitive impairment and individuals diagnosed with schizophrenia. The cognitive functions potentially improved encompassed executive functioning, attention, reaction time, and performance on cognitive tasks.

Furthermore, a study involving 50 adults demonstrated significant enhancements in immediate and general memory, attention, and information-processing speed after consuming 600 mg of ashwagandha extract daily for 8 weeks, compared to a placebo.

Researchers highlighted that compounds present in ashwagandha, including WA, exhibit antioxidant properties within the brain, potentially contributing to cognitive well-being.

Nevertheless, further research is essential to establish robust conclusions regarding the cognitive benefits of ashwagandha supplementation.

6. Sleep Improvement

A study involving 50 adults aged 65-80 revealed that the intake of 600 mg of ashwagandha root daily for 12 weeks notably enhanced sleep quality and bolstered mental alertness upon awakening in comparison to a placebo treatment.

Moreover, a comprehensive review encompassing five high-quality studies indicated that ashwagandha demonstrated a modest yet significant positive impact on overall sleep quality. Additionally, it was observed to diminish anxiety levels and promote increased alertness upon waking. These benefits were particularly prominent among individuals grappling with insomnia and those who consumed more than 600 mg of ashwagandha daily for a duration exceeding 8 weeks.

7. Inflammation Reduction

Ashwagandha may have anti-inflammatory properties due to compounds like withaferin A (WA) found within it.

Animal studies have indicated that WA can reduce levels of inflammatory proteins such as interleukin-10 (IL-10), and there is some evidence suggesting that ashwagandha might also lower inflammatory markers in humans.

In a recent study, participants with COVID-19 were administered an Ayurvedic remedy containing 0.5 grams of ashwagandha along with other herbs twice daily for 7 days. This resulted in decreased levels of inflammatory markers CRP, IL-6, and TNF-α compared to a placebo. However, it's important to note that the Ayurvedic preparation also contained other herbal components, including giloy ghanvati, swasari ras, and tulsi ghanvati.

While ashwagandha holds immense therapeutic potential, its consumption warrants caution, particularly for certain populations and in conjunction with specific medications. Always consult a healthcare professional before integrating ashwagandha or any other supplements into your regimen to ensure safety and efficacy.

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