Mental Health
US Patients Finally Get a Hold of First Postpartum Depression Pill
For many new mothers, the arrival of a child should be a joyous occasion, but for some, it brings the onset of postpartum depression, a condition affecting up to 1 in 5 women.
One such case, recounted by Dr. Misty Richards of UCLA Health, showed the debilitating nature of this condition, which often leads to extreme sadness and anxiety in the weeks following childbirth.
"She wasn't taking showers. She wasn't eating," Richards, 42, remarked, adding that this prompted her husband to take a leave from work to support both his wife and newborn, NBC News reported.
Richards' patient, like hundreds of others treated at her clinic, found herself in a state of despair, even after attempts at outpatient programs. However, a glimmer of hope emerged with the introduction of zuranolone, the first-ever pill specifically designed to combat postpartum depression.
"She tells me she feels like she just woke up," Richards explained, adding: "I truly feel like I'm meeting her for the first time. Her husband was in tears, super grateful. Just a major, grand slam success story - which, by the way, we don't tend to see in psychiatry."
While the FDA greenlit zuranolone in August, its availability has been limited until recently. Psychiatrists are cautiously optimistic about its potential, noting its fast-acting nature and the convenience of at-home administration.
Early reports suggest promising results, with patients experiencing relief from symptoms within days, without significant side effects.
Postpartum depression poses serious risks not only to mothers but also to their children, with potential complications ranging from developmental delays to an increased risk of mortality.
Previous treatments, such as intravenous injections, were associated with sedation and logistical challenges. Zuranolone, however, offers a more accessible alternative, with clinical trials demonstrating its efficacy in alleviating symptoms as early as three days into treatment.
Despite its promise, some patients remain hesitant to embrace zuranolone due to concerns over side effects and practical obstacles. Drowsiness and dizziness are among the reported effects, prompting caution against activities requiring focus or coordination. Additionally, uncertainty regarding its safety during breastfeeding has led some to decline treatment.
Dr. Uruj Haider, serving as the medical director of consultation services at the Massachusetts Child Psychiatry Access Program for Moms, noted that certain patients have voiced apprehension regarding their ability to attend to nighttime feedings due to potential drowsiness from the medication.
She advised patients to ensure the presence of another caregiver overnight, particularly if they have toddlers or lack additional support to watch over their children during the night.
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